Top Artificial Intelligence Startups in San Francisco

Browse 21 startups in San Francisco working in Artificial Intelligence. Every listing below is matched on location and skill set so you can discover the right company faster. Compare profiles and reach out directly.

Signals

San Francisco

Most customer support software is built around a reactive loop: a user runs into a problem, opens a ticket, waits in a queue, and eventually gets an answer. Signals, a Y Combinator Winter 2026 startup, is flipping that model on its head. The company is building an AI customer engagement platform that engages high-value customers […]

Artificial Intelligence B2B SaaS

Slashy

San Francisco

Email remains the universal input tray of knowledge work, and despite two decades of startup promises, most professionals still spend hours a day on it. Slashy, a Y Combinator Summer 2025 company, is taking another run at the category with an AI email assistant it describes as ‘Cursor for Email’ – an agent designed to […]

Artificial Intelligence Email

Frizzle

San Francisco

Frizzle, a Y Combinator Summer 2025 company based in San Francisco, has built an AI product aimed squarely at one of the most stubborn time sinks in American education: grading. Teachers routinely spend more than 10 hours per week – roughly a quarter of all their working time – evaluating student work, especially handwritten math […]

Artificial Intelligence B2B Education

Embedder

San Francisco

The AI-driven coding wave has reshaped how cloud, web, and application engineers work – autocomplete, copilots, and agents are now table stakes for high-level software development. But there is one category of code that has been stubbornly left out: firmware. The low-level C, assembly, and RTOS-adjacent code that runs on microcontrollers, radios, motor drivers, medical […]

Artificial Intelligence B2B Developer Tools

Autosana

San Francisco

Coding agents have gotten remarkably good at writing code. They’re still not great at proving that their code actually works. Autosana, a Summer 2025 Y Combinator company, is out to close that gap with an end-to-end testing layer purpose-built for AI coding agents, covering iOS, Android, and Web apps at once. Autosana’s promise to developers […]

Artificial Intelligence B2B Developer Tools

Hypercubic

San Francisco

Hypercubic, a Fall 2025 Y Combinator-backed startup, is tackling one of the most valuable and least glamorous technology problems in the global economy: the decades-old COBOL codebases running on mainframes that continue to power the core systems of banks, insurers, airlines, telecoms, and retailers. The company is building an AI-native platform to maintain, understand, and […]

Artificial Intelligence B2B Developer Tools

Unsiloed AI

San Francisco

Enterprise AI projects tend to fail at a specific, unglamorous step: parsing the documents. Research teams can spend six months building a document pipeline and still watch fewer than ten percent of those projects make it into production, because generic large language model parsers and legacy OCR systems fall apart on the multimodal PDFs, scanned […]

APIs Artificial Intelligence B2B

Didit

San Francisco

As fraud costs balloon across the internet and KYC-heavy industries juggle an ever-growing stack of identity checks, Didit is pitching a simpler story: one platform, one fast face scan, one predictable per-use price. Founded in 2023 and currently part of Y Combinator’s Winter 2026 cohort, Didit positions itself as “an all-in-one identity platform that lets […]

Artificial Intelligence B2B Fintech

Sourcebot

San Francisco

Sourcebot, an AI code search tool built for massive codebases, is emerging from Y Combinator’s Fall 2025 batch with a message the rest of the AI tooling industry has been slow to embrace. Writing code is no longer the hard part – understanding it is. And for both human engineers and the AI agents increasingly […]

Artificial Intelligence B2B Developer Tools

Zalos

San Francisco

Zalos, a Fall 2025 Y Combinator company, is taking direct aim at the repetitive, time-consuming, and error-prone work that still clogs finance operations at companies of every size. The startup builds AI finance automation software – computer-using agents that log directly into a company’s existing ERP, accounting systems, banking portals, and other CFO tools – […]

Artificial Intelligence B2B Fintech

Corvera

San Francisco

Consumer packaged goods brands have long been celebrated for their marketing and product innovation, but their back-office operations remain stuck in the spreadsheet era. Corvera, a Y Combinator–backed startup, is attacking that gap with an AI agent workforce purpose-built for CPG operations – and the early traction suggests the market has been waiting for exactly […]

Artificial Intelligence B2B SaaS

Clicks

San Francisco

A new Y Combinator–backed startup wants to rewrite the economics of the business process outsourcing industry from the ground up. Clicks, a Fall 2025 YC company, is building what it calls an AI-native BPO: a service layer that replaces traditional offshore teams and shared service centers by deploying AI agents that operate customers’ existing tools […]

Artificial Intelligence

Cumulus Labs

San Francisco

Cumulus Labs, a Y Combinator Winter 2026 startup, is betting that the next competitive axis in AI is not model quality but inference economics. The company is building an AI inference optimization platform – what it calls the fastest multimodal inference operating system – aimed squarely at AI teams who want dramatically lower costs and […]

Artificial Intelligence B2B Developer Tools

Human Archive

San Francisco

Human Archive, a Winter 2026 Y Combinator company, is pursuing one of the least glamorous and most consequential bottlenecks in modern robotics: data. The startup, founded in 2026 by Raj Patel, Rushil Agarwal, Samay Maini, and Shloke Patel, specializes in AI robotics training data – positioning itself as the multimodal data provider for frontier labs […]

Artificial Intelligence Machine Learning Robotics

Luel

San Francisco

Training data has quietly become one of the most contested assets in artificial intelligence. Frontier labs need staggering volumes of high-quality, diverse, and – increasingly – legally defensible data to push their models forward, yet the supply side of that equation is a mess of scraped corpora, unclear licensing, and reactive lawsuits. Luel, a Y […]

Artificial Intelligence B2B Machine Learning

Voxel Energy

San Francisco

Voxel Energy, a Y Combinator-backed startup in the Winter 2026 batch, is taking aim at one of the most urgent bottlenecks in the AI boom: getting electricity to data centers fast enough to keep up with compute demand. Co-founded by Casey Spencer, Max Pfeiffer, and Evan Schmidt, Voxel is building off-grid data center power systems […]

Artificial Intelligence Energy Hardware

Taiga

San Francisco

Medical billing is one of the quiet crises of American healthcare. Small practices lose meaningful revenue to coding errors, claim denials, and the bureaucratic drag of dealing with insurers – all while their staff spend hours on work that has nothing to do with patient care. Taiga, a San Francisco startup in Y Combinator’s Spring […]

Artificial Intelligence

Lab0

San Francisco

Enterprise software has a dirty open secret: the tool is rarely the hard part. Implementation is. Rollouts of ERPs, data platforms, and – increasingly – enterprise AI systems, routinely take months and demand armies of system integrators and forward-deployed engineers to wire up, configure, and tune. Lab0, a San Francisco startup in Y Combinator’s Spring […]

Artificial Intelligence B2B

Kuli

San Francisco

Kuli, a Y Combinator Spring 2026 company, is rebuilding the AI influencer marketing stack around a single agent that actually watches social video content the way a seasoned marketer would. Where legacy platforms hand marketing teams yet another searchable database and a CRM, Kuli positions itself as the orchestration layer that takes work off their […]

Artificial Intelligence B2B SaaS

Modern

San Francisco

Modern is taking aim at one of the quiet productivity drains of large organizations: the endless stream of low-complexity, high-volume internal requests that clog up IT help desks, HR mailboxes, and finance approval queues. The Y Combinator Spring 2026 company believes AI agents can resolve more than 80 percent of those requests automatically – and […]

AIOps Artificial Intelligence B2B

Gigacatalyst

San Francisco

For years, SaaS vendors have promised configurability – a dropdown here, a custom field there, maybe a Zapier integration if the customer was sophisticated enough to wire one up. Gigacatalyst, a Y Combinator Spring 2026 startup, argues that “configurable” was always a polite word for “not quite customized.” Its answer is to give SaaS companies […]

Artificial Intelligence Enterprise No-code