Top AI Startups in San Francisco

Browse 12 startups in San Francisco working in AI. Every listing below is matched on location and skill set so you can discover the right company faster. Compare profiles and reach out directly.

Shor

San Francisco

Shor, a fintech startup in Y Combinator’s Summer 2025 batch, is betting that the next generation of global payroll will run on stablecoins and AI agents rather than on legacy banking rails. The company has launched what it calls an AI-native Employer-of-Record, aimed at giving remote teams a faster, cheaper, and fully compliant way to […]

AI B2B Fintech

Pixley AI

San Francisco

Children’s entertainment is in an awkward moment. YouTube and Netflix produce more content than any kid could watch in a lifetime, but parents increasingly find it overstimulating, repetitive, and short on the kind of imaginative play that earlier generations took for granted. Pixley AI, a Y Combinator Fall 2025 startup, is betting that the answer […]

AI AI-Enhanced Learning Generative AI

VibeFlow

San Francisco

The first wave of AI-powered app builders fixed an obvious problem: shipping a usable frontend from a prompt. Tools like Lovable and v0 compressed hours of component tweaking into a few iterative descriptions, letting non-engineers and engineers alike move faster than ever on the user-facing layer. VibeFlow, a Y Combinator Summer 2025 company, is building […]

AI B2B Consumer

Veritus

San Francisco

Loan servicing and collections has historically been one of the most labor-intensive – and most regulated – corners of consumer finance. Lenders need to recover delinquent balances, treat borrowers respectfully, and stay within an ever-tightening compliance perimeter, all while keeping the cost-to-collect manageable. Veritus, a Y Combinator Summer 2025 company based in San Francisco, is […]

AI Fintech Lending

Zarna

San Francisco

Inside a private equity firm, the most numerate, sleep-deprived people in the building are usually the associates. They build leveraged buyout models, dissect confidential information memoranda, draft investment committee memos, update CRMs, and chase down the long tail of diligence questions that turn an idea into a deal. Zarna, a Y Combinator Fall 2025 startup […]

AI Investments

Anto Biosciences

San Francisco

Drug development has long been hobbled by a quietly devastating problem: the same medicine that works for one patient can prove ineffective – or even toxic – for the next. Increasingly, the suspect is the trillions of microbes living inside us. Anto Biosciences, a Y Combinator Fall 2025 company, believes microbiome drug development can finally […]

AI Biotech Drug discovery

Aurorin CAD

San Francisco

For a generation of mechanical engineers, the everyday experience of CAD has been defined by a handful of incumbents – Solidworks, NX, Creo, Catia, Fusion 360, Onshape – and a strangely consistent set of complaints. The software is slow. Files take minutes (sometimes hours) to open. Design workflows are tedious, multi-step, and hostile to iteration. […]

AI Software Development

Ontora

San Francisco

Management consultants have long charged seven-figure fees to do one seemingly simple thing: talk to everyone in a company and figure out what’s broken. Ontora, a San Francisco-based startup in Y Combinator’s Spring 2026 batch, is betting that the whole exercise can be automated. The company has launched an AI operational intelligence platform that interviews […]

AI Analytics B2B

Paper Star

San Francisco

Food tracking apps have a retention problem. Calorie counters promise transformation but demand tedium, and most users churn within a few weeks. Paper Star, a San Francisco startup in Y Combinator’s Spring 2026 batch, thinks the category needs a rebuild – one that trades spreadsheets for stories. Its first product, Napkin Math, is an AI-powered […]

AI Consumer Digital Health

Korso

San Francisco

Ask any plant manager where the bottlenecks are and the answer rarely involves the factory floor itself. It is the paperwork around it – the RFQs that need processing, the quotes that need chasing, the suppliers that need reminding, and the production schedules that need rewiring every time reality intrudes. Korso, a Y Combinator Spring […]

AI Manufacturing SaaS

Gojiberry AI

San Francisco

Outbound sales has become an arms race of volume, and small teams are losing. Cold lists, mass sequences, and blanket personalization tools have driven reply rates to historic lows while inboxes become harder to crack. Gojiberry AI, a Y Combinator Spring 2026 company, is pitching a different approach: an AI outbound sales platform with a […]

AI B2B SaaS

Manicule

San Francisco

Developer documentation has always been the quiet infrastructure of software. It determines which APIs get adopted, which SDKs get abandoned, and which products get replaced. Manicule, a Y Combinator Spring 2026 startup, believes that infrastructure is overdue for a rebuild – and that the rebuild looks more like an AI-native studio than a freelance writing […]

AI B2B Developer Tools