Top Generative AI Startups in USA

Browse 14 startups in USA working in Generative AI. Every listing below is matched on location and skill set so you can discover the right company faster. Compare profiles and reach out directly.

Speedy Labs

San Francisco

Speedy Labs, a Y Combinator Winter 2023 company, is taking aim at a financial problem that quietly drains billions of dollars from manufacturers and distributors every year: the opaque, spreadsheet-driven world of rebate management. Founded in 2023 by Jatin Mehta, Ranti Dev Sharma, and Ayush Jasuja, Speedy Labs offers an AI-powered platform that helps industrial […]

Artificial Intelligence B2B Generative AI

kapa.ai

New York

When OpenAI, N8N, Mapbox, Mixpanel, Nokia, and Grafana all lean on the same startup to answer their users’ technical questions, something interesting is happening beneath the surface of the AI hype cycle. That startup is kapa.ai, a Summer 2023 Y Combinator company founded in 2023 by Emil Soerensen and Finn Bauer, and it has methodically […]

AI AI Assistant Artificial Intelligence

Morph

San Francisco

San Francisco, CA — The first generation of AI coding assistants proved that language models could write code. The next generation is about something harder: agents that can work inside real codebases for long-running, multi-step engineering tasks without getting slow, expensive, or unreliable. Morph, a Y Combinator Summer 2023 company based in San Francisco, is […]

AI API Artificial Intelligence

sync.

San Francisco

sync., an AI lipsync tool for video content creators and a Y Combinator Winter 2024 company, is drawing industry attention as it scales operations following its accelerator cohort. The company’s mission is to make video as fluid and editable as a word document — letting creators record once, revise at will, and post, without re-recording […]

AI Artificial Intelligence B2B

VideoGen

San Francisco

VideoGen, a Summer 2024 Y Combinator-backed startup, is taking on one of the most universally painful problems in content creation: making professional video is hard, slow, and expensive. Founded in 2023 by Anton Koenig and David Grossman, VideoGen lets anyone generate professional, copyright-free videos in seconds using AI — a proposition that has already won […]

AI Artificial Intelligence Developer Tools

Roark

San Francisco

Roark, a Y Combinator Winter 2025 company, is betting that the difference between a novelty and a trustworthy product comes down to rigorous, automated testing — and it is building the platform to make that possible. As enterprises race to deploy voice agents for customer support, sales, and operations, a quieter problem has surfaced behind […]

AI Analytics Artificial Intelligence

Cedar

San Francisco

Cedar, a Winter 2025 Y Combinator company, is building a new kind of copilot that picks up where the training program ends — one that captures the playbook of the best reps and puts it in front of every AE, every day. The hardest part of scaling a go-to-market team isn’t hiring — it’s ramping. […]

AI B2B CRM

ISSEN

New York

ISSEN, a Y Combinator Fall 2024 company, is betting that real-time voice AI can finally close the gap between vocabulary drills and real conversation — and has built an AI conversational tutor designed to make fluency, not streaks, the goal. Language apps have gotten very good at vocabulary drills and very bad at conversation. Most […]

AI Consumer Education

Wildcard

San Francisco

A new layer of commerce is forming inside AI assistants, and most brands cannot yet see what is happening inside it. When a shopper asks ChatGPT, Gemini, Claude, or another AI assistant to recommend running shoes, protein powder, office supplies, or a lightweight laptop, an entirely new buying journey unfolds. It is not a search […]

Artificial Intelligence E-commerce Generative AI

Pixley AI

San Francisco

Children’s entertainment is in an awkward moment. YouTube and Netflix produce more content than any kid could watch in a lifetime, but parents increasingly find it overstimulating, repetitive, and short on the kind of imaginative play that earlier generations took for granted. Pixley AI, a Y Combinator Fall 2025 startup, is betting that the answer […]

AI AI-Enhanced Learning Generative AI

Anto Biosciences

San Francisco

Drug development has long been hobbled by a quietly devastating problem: the same medicine that works for one patient can prove ineffective – or even toxic – for the next. Increasingly, the suspect is the trillions of microbes living inside us. Anto Biosciences, a Y Combinator Fall 2025 company, believes microbiome drug development can finally […]

AI Biotech Drug discovery

Absurd

San Francisco

The pitch for AI video has been around for years, but the gap between viral demos and ads that brands will actually run on television, billboards, and paid social has remained stubbornly wide. Absurd, a Y Combinator Fall 2025 company, thinks it has cracked the operating model that closes that gap. The startup describes itself […]

Advertising Generative AI Marketing

Bear

San Francisco

For two decades, the marketing stack has been organized around a familiar funnel: someone searches Google, lands on a website, and converts through a carefully optimized series of pages. That funnel is starting to break. Increasingly, prospective customers do their research inside ChatGPT, Perplexity, and other AI agents – which then surface a small set […]

B2B Generative AI SaaS

Amboras

San Francisco

The e-commerce playbook of the 2010s – pick a Shopify theme, hire an agency, tweak funnels, and run paid ads – is looking increasingly expensive and slow against a new generation of AI-native competitors. Amboras is positioning itself at the front of that shift. The Y Combinator Spring 2026 startup is building an autonomous AI […]

B2B E-commerce Generative AI