Top Artificial Intelligence Startups in USA

Browse 40 startups in USA working in Artificial Intelligence. Every listing below is matched on location and skill set so you can discover the right company faster. Compare profiles and reach out directly.

Clicks

San Francisco

A new Y Combinator–backed startup wants to rewrite the economics of the business process outsourcing industry from the ground up. Clicks, a Fall 2025 YC company, is building what it calls an AI-native BPO: a service layer that replaces traditional offshore teams and shared service centers by deploying AI agents that operate customers’ existing tools […]

Artificial Intelligence

Cumulus Labs

San Francisco

Cumulus Labs, a Y Combinator Winter 2026 startup, is betting that the next competitive axis in AI is not model quality but inference economics. The company is building an AI inference optimization platform – what it calls the fastest multimodal inference operating system – aimed squarely at AI teams who want dramatically lower costs and […]

Artificial Intelligence B2B Developer Tools

Human Archive

San Francisco

Human Archive, a Winter 2026 Y Combinator company, is pursuing one of the least glamorous and most consequential bottlenecks in modern robotics: data. The startup, founded in 2026 by Raj Patel, Rushil Agarwal, Samay Maini, and Shloke Patel, specializes in AI robotics training data – positioning itself as the multimodal data provider for frontier labs […]

Artificial Intelligence Machine Learning Robotics

Luel

San Francisco

Training data has quietly become one of the most contested assets in artificial intelligence. Frontier labs need staggering volumes of high-quality, diverse, and – increasingly – legally defensible data to push their models forward, yet the supply side of that equation is a mess of scraped corpora, unclear licensing, and reactive lawsuits. Luel, a Y […]

Artificial Intelligence B2B Machine Learning

Voxel Energy

San Francisco

Voxel Energy, a Y Combinator-backed startup in the Winter 2026 batch, is taking aim at one of the most urgent bottlenecks in the AI boom: getting electricity to data centers fast enough to keep up with compute demand. Co-founded by Casey Spencer, Max Pfeiffer, and Evan Schmidt, Voxel is building off-grid data center power systems […]

Artificial Intelligence Energy Hardware

Taiga

San Francisco

Medical billing is one of the quiet crises of American healthcare. Small practices lose meaningful revenue to coding errors, claim denials, and the bureaucratic drag of dealing with insurers – all while their staff spend hours on work that has nothing to do with patient care. Taiga, a San Francisco startup in Y Combinator’s Spring […]

Artificial Intelligence

Lab0

San Francisco

Enterprise software has a dirty open secret: the tool is rarely the hard part. Implementation is. Rollouts of ERPs, data platforms, and – increasingly – enterprise AI systems, routinely take months and demand armies of system integrators and forward-deployed engineers to wire up, configure, and tune. Lab0, a San Francisco startup in Y Combinator’s Spring […]

Artificial Intelligence B2B

Kuli

San Francisco

Kuli, a Y Combinator Spring 2026 company, is rebuilding the AI influencer marketing stack around a single agent that actually watches social video content the way a seasoned marketer would. Where legacy platforms hand marketing teams yet another searchable database and a CRM, Kuli positions itself as the orchestration layer that takes work off their […]

Artificial Intelligence B2B SaaS

Modern

San Francisco

Modern is taking aim at one of the quiet productivity drains of large organizations: the endless stream of low-complexity, high-volume internal requests that clog up IT help desks, HR mailboxes, and finance approval queues. The Y Combinator Spring 2026 company believes AI agents can resolve more than 80 percent of those requests automatically – and […]

AIOps Artificial Intelligence B2B

Gigacatalyst

San Francisco

For years, SaaS vendors have promised configurability – a dropdown here, a custom field there, maybe a Zapier integration if the customer was sophisticated enough to wire one up. Gigacatalyst, a Y Combinator Spring 2026 startup, argues that “configurable” was always a polite word for “not quite customized.” Its answer is to give SaaS companies […]

Artificial Intelligence Enterprise No-code
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